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Prediction of Intrinsically Unstructured Proteins
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IUPred
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Intrinsically unstructured/disordered proteins have no single well-defined
tertiary structure in their native, functional state. Our server recognizes such regions from the amino acid
sequence based on the
estimated pairwise energy content. The underlying assumption is that globular
proteins are composed of amino acids which have the potential to form a large number of favorable
interactions, whereas intrinsically unstructured proteins (IUPs) adopt no stable structure because their amino acid composition does not
allow sufficient favorable interactions to form.
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References
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The Pairwise Energy Content Estimated from Amino Acid Composition Discriminates
between Folded and Intrinsically Unstructured Proteins
Zsuzsanna Dosztányi, Veronika Csizmók, Péter Tompa and
István Simon
J. Mol. Biol. (2005) 347, 827-839.
IUPred: web server for the prediction of intrinsically unstructured regions of
proteins based on estimated energy content
Zsuzsanna Dosztányi, Veronika Csizmók, Péter Tompa and
István Simon
Bioinformatics (2005) 21, 3433-3434.
Software
The software is freely available to academic users upon request.
Requests can be sent to zsuzsa at enzim dot hu.
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